The October long weekend quickly approaches, which means double demerits are enforced from Friday until the end of Monday in NSW.

Thousands of people are expected to travel with eased COVID-19 restrictions to drive interstate.

However, Police and Emergency Services David Elliot said that police will be out in force across the state for Operation Slowdown, with a focus on mobile phone usage.

Mobile Phone Detection Cameras will be out, with drivers hit with a $457 fine and 10 demerit points if caught using their phone behind the wheel.

“One or two mistakes on the road could cost you your licence,” Mr Elliott said on Wednesday.

"One road fatality is one too many. Stick to the speed limit, put your phone down, and observe the road rules. We want people to arrive at their destination safely," Mr Elliott said.

On the last long weekend in October, six people were killed on NSW roads.

“That is six people too many,” Regional Transport and Roads Minister Paul Toole said.

"We are asking everyone to plan your trip in advance, allow plenty of extra travel and be patient on the roads," he said.

Police in NSW are also targeting speeding, seat belt and motorcycle helmet offences, with the penalty for driving without a seatbelt during a double demerit period being six points off your licence.