Melbourne Premier Daniel Andrews has blamed "complacency" on Melbourne citizens for the second wave around coronavirus.

Critics say the true blame rests with the Victorian Premier himself and are asking for his resignation.

There is an "unsustainable" spike in new cases of coronavirus and prompted the stage three lockdown of Melbourne for the next six weeks.

“I think a sense of complacency has crept into us as we let our frustrations get the better of us,” Mr Andrews said. “I think that each of us know someone who has not been following the rules as well as they should have.”

The beginning of this second wave of infections has been linked to a failure in Victoria's mandatory hotel quarantine procedures, which the Victorian government was responsible for.

Liberal Opposition leader Michael O’Brien said yesterday the lockdown of Melbourne is the “catastrophic failure of Daniel Andrews’ failure on hotel quarantine”.

Mr Andrews was asked directly at a press conference today if he felt "community anger" towards his government undermined his credibility.

“I am accountable – there’s never been a doubt about that,” he said.

“I am accountable for what happens across our state. That’s what being the leader of the state is all about. At the same time, that job requires me to make not just the popular calls, but the really difficult, hard calls.”

Dr Margaret Heffernan OAM said that the government's conduct contributed to "message and compassion fatigue", especially as Victorians were allowed to protest for Black Lives Matter during the lockdown.

“In Victoria … a lack of resilience among sectors of the population (was) compounded by contradictory messages from government – ‘constrain social behaviours, but it is OK to mass protest’ – and led to confusion and lack of trust in our mandated leaders,” Dr Heffernan said.

There is a clear sense of anger after yesterday's announcement as talkback radio was flooded with upset calls.

Many were annoyed that they had been blamed for the return of COVID-19 cases by Mr Andrews.

“Well, I made a number of comments yesterday and I think that’s an accurate description of the way some people are behaving,” he said, adding: “That’s not every Victorian.”

When asked by a reporter, the Premier said he wasn’t considering resigning.

“What I’m not just considering, but delivering, is the response to this pandemic and seeing this through. That’s what’s most important and it’s what I’m going to get done.”