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Woman cured of Type 1 diabetes in life-changing clinical trial

<p>Marlaina Goedel was diagnosed with Type 1 diabetes when she was just five-years-old, and not only was the disease controlling her, but it almost cost her life. </p> <p>"I've crashed my car into a brick building before having a diabetic attack while driving," Goedel recalled. </p> <p>Her condition was so extreme that she felt robbed of a normal childhood, telling the <em>Daily Mail </em>that she was in and out of hospital with  life-threatening diabetic ketoacidosis, which causes toxic chemicals to build up in the blood due to a lack of insulin.</p> <p>Now 30-years-old, the Illinois woman no longer needs daily insulin shots and can finally enjoy sugar again thanks to a pioneering stem cell therapy that has cured her of type 1 diabetes. </p> <p>Goedel was one of three Americans who have been cured of their type 1 diabetes thanks to the clinical trial involving an islet cell transplant. </p> <p>It is a one-off infusion that involved transplanting islet cells into her liver to help her body produce insulin on its own. </p> <p>After four weeks, she no longer needed to take insulin. </p> <p>"[My doctor] said, ‘Mark it on your calendar. Today is the day. Stop all insulin,'" Goedel said of the life-changing moment. </p> <p>"I just went quiet and finally said, ‘I’m here. I’m in shock. I’m going to need you to repeat that.’"</p> <p>The trial was being run at the University of Chicago Medicine Transplant Institute. </p> <p>While Islet cell transplants isn't a new procedure, the current anti-rejection medication used can be toxic to the transplanted cells, potentially making it less effective over time. </p> <p>The clinical trial that ran at the university tested out a new antibody called tegoprubart, which was given to Goedel and the two other patients. </p> <p>Tegoprubart is made from lab-made antibodies that trick the immune system into thinking the body made the cells on its own, preventing them from being rejected. </p> <p>The patients were then given islet cells from a deceased donor's pancreas, which were then infused into the patient's small blood vessels in their liver. Those cells then lodged into the blood vessels and started producing insulin. </p> <p>For Goedel the only side effect of the procedure was "feeling like I got punched in the ribs,"  with the procedure lasting just an hour. </p> <p>"The cure is out there," Goedel told the <em>Daily Mail. </em></p> <p>With her new lease on life, Goedel plans to go back to school and go horse riding without worrying about suffering an attack and causing an accident. </p> <p>"It took a while to get used to saying, 'I am cured. I am diabetes free.' It's been very freeing," she said.</p> <p>"No one should have to live with this disease. I know that now more than ever."</p> <p><em>Images: Good Morning America/ UChicago Medicine</em></p> <p> </p>

Caring

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"Absolute breakthrough": New hope in search for Motor Neurone Disease cure

<p>Melbourne researchers are one step closer to finding a cure for Motor Neurone Disease, with the help technology and stem cell research. </p> <p>Scientists at The Florey Institute of Neuroscience and Mental Health have developed a world-first technology that will speed up the drug testing process to help find an effective treatment and maybe even a cure for the disease. </p> <p>New machines at the institute can now help determine whether drugs on the market could be used to treat MND in just weeks, a process which previously took decades. </p> <p>"This is an absolute breakthrough, it's at the cutting edge of technology," Florey MND researcher Professor Brad Turner said.</p> <p>Animal cells were previously used to test the efficacy of MND drugs, but now thanks to more than 100 MND patients who donated their skin cells to the institute, researchers have a library of stem cells to work with. </p> <p>The human stem cells can provide scientists with the full scope of the disease, something that they were previously unable to do with just animal cells. </p> <p>"This is really a game-changer in that we can use their own cells, and we can test drugs directly on their own cells," Florey MND researcher and neurologist Dr Thanuja Dharmadasa said. </p> <p>Large scale screening will commence thanks to a $5 million grant from the Australian Medical Research Future Fund.</p> <p><span style="font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Open Sans', 'Helvetica Neue', sans-serif;">The research is expected to help people like Phil Camden who has been living with the disease for 10 years. </span></p> <p>"That's the key to all of us living with MND... we want to do what we can while we can," Camden said.</p> <p>"We know we're not doing it to find a cure for us. We're doing it for those in the future, my grandkids and their children."</p> <p>Scientists believe that medication or a cocktail of drugs tailored specifically to a patient is the way forward when it comes to treating the disease. </p> <p>"Therefore your drug treatments are tailed back to the clinical makeup in the dish and we call that personalised medical treatment," Turner said.</p> <p><em>Image: Nine News</em></p> <p> </p>

Caring

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Doting dad sells everything he owns to develop cure for son's "incurable" condition

<p>A dedicated father has drained his life savings to help find a cure for his son's "incurable" disorder. </p> <p>Terry Pirovolakis, a 44-year-old IT director, was hellbent on finding a cure for his six-year-old son Michael after he was diagnosed with Spastic paraplegia 50 (SPG50): a degenerative neurological condition that affects less than 100 people worldwide. </p> <p>SPG50 affects children's development, leading to cognitive impairment, muscle weakness, and paralysis over the course several years, often ending in death usually before a patient reaches the age of 30.</p> <p>"They said he'd never walk or talk, and would need support for the rest of his life," he recalled of the 2018 diagnosis. </p> <p>"They told us to just go home and love him - and said he would be paralysed from the waist down by age 10, and quadriplegic by age 20," he continued. </p> <p>Determined to save his son, Terry drained his life savings to start researching potential cures rooted in gene therapy, after reading countless journals on the subject and meeting with experts around the world. </p> <p>Terry said, "We then liquidated our life savings, refinanced our home and paid a team at the University of Texas Southwestern Medical Center to create a proof of concept to start Michael's gene therapy."</p> <p>The father soon signed a contract to start a gene therapy program, consisting of injecting cerebral spinal fluid into the patient's back, and after years of lab work, the treatment started to take, and on December 30th 2021, the government <a id="mol-70453400-6948-11ef-9b54-1d20db350cbd" href="https://www.dailymail.co.uk/news/canada/index.html" target="_self"></a>moved it forward.</p> <p>"On March 24, 2022, my son was the first person to ever get treated with gene therapy at SickKids in Toronto," Pirovolakis, a father of three, told <em>Fox News</em> in detailing his medical odyssey.</p> <p>Michael was the first to receive his father's one-time treatment, after Pirovolakis quit his job and started a nonprofit in California to devote himself to the cause.</p> <p>The company, named Elpida Therapeutics, after the Greek word for 'hope', now has five employees and 20 consultants, with Michael now on the mend.</p> <p>Since being treated, the youngster's condition seems to have stabilised, and he is now able to use a device to communicate with his family and caregivers.</p> <p>Another three children who were able to receive the remaining doses from Pirovolakis' first batch, as the drug still costs about $1million to make for each child, are also seeing positive results. </p> <p>"When I heard that no one was going to do anything about it, I had to - I couldn't let them die," Pirovolakis said. "We decided that we had to help other kids."</p> <p>Despite it being approved, big pharmaceutical companies have been slow to manufacture the drug, with several firms rejecting the prospect when proposed, Pirovolakis said</p> <p>"No investor is going to give you money to treat a disease that is not going to make money," he said. "That's the dilemma we're in."</p> <p>Pirovolakis said that when his son was diagnosed, he was told the boy would be paralysed from the waist down by the age of ten and quadriplegic by the age of 20, forcing the father to do everything he can.</p> <p>"We were told he would never speak or walk, and that he will have severe developmental delays. I just couldn't accept that fate for my child," he said.</p> <p>"The technology to cure our children is already here. I hope that someone with immense wealth - and more importantly, the vision and influence - will step in."</p> <p><em>Image credits: Facebook</em></p>

Money & Banking

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Drugs like Ozempic won’t ‘cure’ obesity but they might make us more fat-phobic

<p><em><a href="https://theconversation.com/profiles/emma-beckett-22673">Emma Beckett</a>, <a href="https://theconversation.com/institutions/unsw-sydney-1414">UNSW Sydney</a></em></p> <p>Many have <a href="https://www.economist.com/leaders/2023/03/02/new-drugs-could-spell-an-end-to-the-worlds-obesity-epidemic">declared</a> drugs like Ozempic could “end obesity” by reducing the appetite and waistlines of millions of people around the world.</p> <p>When we look past the hype, this isn’t just untrue – it can also be harmful. The focus on weight, as opposed to health, is a feature of <a href="https://www.sciencedirect.com/science/article/abs/pii/S0277539521001217">diet culture</a>. This frames the pursuit of thinness as more important than other aspects of physical and cultural wellbeing.</p> <p>The Ozempic buzz isn’t just rooted in health and medicine but plays into ideas of <a href="https://butterfly.org.au/weight-bias-fatphobia-diet-culture/#:%7E:text=Weight%20bias%2C%20sometimes%20also%20called,or%20being%20around%20fat%20people.">fat stigma and fat phobia</a>. This can perpetuate fears of fatness and fat people, and the behaviours that <a href="https://link.springer.com/article/10.1186/S12916-018-1116-5">harm people who live in larger bodies</a>.</p> <h2>Not the first ‘miracle’ weight-loss drug</h2> <p>This isn’t the first time we have heard that weight-loss drugs will change the world. Ozempic and <a href="https://www.ncbi.nlm.nih.gov/books/NBK551568/">its family</a> of GLP-1-mimicking drugs are the <a href="https://theconversation.com/ozempic-is-in-the-spotlight-but-its-just-the-latest-in-a-long-and-strange-history-of-weight-loss-drugs-209324">latest in a long line of weight loss drugs</a>. Each looked promising at the time. But none have lived up to the hype in the long term. Some have even been withdrawn from sale due to <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126837/">severe side effects</a>.</p> <p>Science does improve <a href="https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(20)30028-8/fulltext">incrementally</a>, but diet culture also keeps us on a cycle of hope for the next <a href="https://sahrc.org/2022/04/diet-culture-a-brief-history/">miracle cure</a>. So drugs like Ozempic might not deliver the results individuals expect, continuing the cycle of hope and shame.</p> <h2>Ozempic doesn’t work the same for everyone</h2> <p>When we talk about the results of studies using Ozempic, we often <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719041/">focus on the average</a> (also known as the mean) results or the maximum (or peak) results. So, studies might <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486455/">show</a> those using the drug lost an average of 10.9% of their body weight, but some lost more than 20% and others less than 5%</p> <p>What we don’t talk about as much is that responses are variable. Some people are “<a href="https://www.sciencedirect.com/science/article/pii/S2212877820301769">non-responders</a>”. This means not everyone loses as much weight as the average, and some don’t lose weight at all. For some people, the side-effects will outweigh the benefits.</p> <p>When people are on drugs like Ozempic, their blood sugar is better controlled by enhancing the release of insulin and reducing the levels of another hormone called glucagon.</p> <p>But there is greater variability in the amount of <a href="https://www.sciencedirect.com/science/article/pii/S2212877820301769#bib88">weight lost</a> than the variability in blood sugar control. It isn’t clear why, but is likely due to differences in genetics and lifestyles, and weight being more complex to regulate.</p> <h2>Treatment needs to be ongoing. What will this mean?</h2> <p>When weight-loss drugs do work, they are only effective while they’re being taken. This means that to keep the weight off people need to keep taking them long term. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542252/">One study found</a> an average weight loss of more than 17% after a year on Ozempic became an average net weight loss of 5.6% more than two years after stopping treatment.</p> <p>Short-term side effects of drugs like Ozempic include dizziness, nausea, vomiting and other gastrointestinal upsets. But because these are new drugs, we simply don’t have data to tell us if side effects will increase as people take them for longer periods.</p> <p>Nor do we know if <a href="https://www.medicalnewstoday.com/articles/why-weight-loss-drugs-stop-working-how-to-break-past-ozempic-plateau#:%7E:text=A%20lifetime%20commitment%20to%20Ozempic&amp;text=By%20these%20standards%2C%20such%20drugs,long%2Dterm%20risk%20is%20unknown.">effectiveness will be reduced</a> in the long term. This is called <a href="https://www.cancer.gov/publications/dictionaries/cancer-terms/def/drug-tolerance#:%7E:text=A%20condition%20that%20occurs%20when,or%20different%20medicine%20is%20needed.">drug tolerance</a> and is documented for other long-term treatments such as antidepressants and chemotherapies.</p> <h2>Biology is only part of the story</h2> <p>For some people, using GLP-1-mimicking drugs like Ozempic will be validating and empowering. They will feel like their biology has been “normalised” in the same way that blood pressure or cholesterol medication can return people to the “normal” range of measures.</p> <p>But biologically, obesity <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202176/#:%7E:text=Obesity%20behaves%20as%20complex%20polygenic,about%2080%25%20(3).">isn’t solely about GLP-1 activity</a> with <a href="https://www.worldobesity.org/what-we-do/our-policy-priorities/the-roots-of-obesity">many other</a> hormones, physical activity, and even our gut microbes involved.</p> <p>Overall, <a href="https://www.ncbi.nlm.nih.gov/books/NBK278977/">obesity is complex and multifaceted</a>. Obesity isn’t just driven by personal biology and choice; it has social, cultural, political, environmental and economic determinants.</p> <h2>A weight-centred approach misses the rest of the story</h2> <p>The weight-centred approach <a href="https://butterfly.org.au/body-image/health-not-weight/#:%7E:text=Health%20and%20wellbeing%20are%20multi,on%20their%20size%20or%20appearance.">suggests that leading with thinness means health will follow</a>. But changing appetite is only part of the story when it comes to health.</p> <p>Obesity often <a href="https://www.sciencedirect.com/science/article/pii/S2667368123000335#:%7E:text=Obesity%20related%20malnutrition%20can%20also,%5D%2C%20%5B7%5D%5D.">co-exists with malnutrition</a>. We try to separate the effects in research using statistics, but focusing on the benefits of weight-loss drugs without addressing the underlying malnutrition means we aren’t likely to see the <a href="https://www.wsj.com/articles/ozempic-diet-exercise-healthy-43eee86c">improved health outcomes in everyone who loses weight</a>.</p> <h2>Obesity isn’t an issue detached from people</h2> <p>Even when it is well-intentioned, the rhetoric around the joy of “ending the obesity epidemic” can <a href="https://theconversation.com/ozempic-the-miracle-drug-and-the-harmful-idea-of-a-future-without-fat-211661">harm people</a>. Obesity doesn’t occur in isolation. It is people who are obese. And the celebration and hype of these weight-loss drugs can reinforce harmful fat stigma.</p> <p>The framing of these drugs as a “cure” exacerbates the binary view of thin versus fat, and healthy versus unhealthy. These are not binary outcomes that are good or bad. Weight and health exist on a spectrum.</p> <p>Ironically, while fat people are told they need to lose weight for their health, they are also <a href="https://www.dailytelegraph.com.au/news/nsw/ozempic-shame-why-users-are-embarrassed-to-admit-using-weight-loss-wonder-drug/news-story/ee52a819c69459afe6576d25988f9bd6">shamed for “cheating” or taking shortcuts</a> by using medication.</p> <h2>Drugs are tools, not silver bullets</h2> <p>The creation of these drugs is a start, but they remain expensive, and the hype has been followed by <a href="https://www.tga.gov.au/safety/shortages/information-about-major-medicine-shortages/about-ozempic-semaglutide-shortage-2022-and-2023#:%7E:text=Consumer%20Medicine%20Information%20.-,Why%20the%20Ozempic%20shortage%20happened,label%20prescribing%20for%20weight%20loss.">shortages</a>. Ultimately, complex challenges aren’t addressed with simple solutions. This is particularly true when people are involved, and even more so when there isn’t even an agreement on what the challenge is.</p> <p>Many organisations and individuals see obesity is a disease and believe this framing helps people to seek treatment.</p> <p>Others think it’s unnecessary to attach medical labels to body types and <a href="https://www.forbes.com/sites/geoffreykabat/2013/07/09/why-labeling-obesity-as-a-disease-is-a-big-mistake/?sh=5ca95cc2103b">argue</a> it confuses risk factors (things that are linked to increased risk of illness) with illness itself.</p> <p>Regardless, two things will always remain true. Drugs can only ever be tools, and those tools need to be applied in a context. To use these tools ethically, we need to remain mindful of who this application harms along the way.</p> <hr /> <p><em>Read the other articles in The Conversation’s <a href="https://theconversation.com/au/topics/ozempic-series-154673">Ozempic series</a> here.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/219309/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></em></p> <p><em><a href="https://theconversation.com/profiles/emma-beckett-22673">Emma Beckett</a>, Adjunct Senior Lecturer, Nutrition, Dietetics &amp; Food Innovation - School of Health Sciences, <a href="https://theconversation.com/institutions/unsw-sydney-1414">UNSW Sydney</a></em></p> <p><em>Image credits: Getty Images </em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/drugs-like-ozempic-wont-cure-obesity-but-they-might-make-us-more-fat-phobic-219309">original article</a>.</em></p>

Body

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"I’m not going to be cured". How breast cancer awareness and support sidelines people with metastatic disease

<p><em><a href="https://theconversation.com/profiles/sophie-lewis-111177">Sophie Lewis</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a>; <a href="https://theconversation.com/profiles/andrea-smith-15431">Andrea Smith</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a>, and <a href="https://theconversation.com/profiles/katherine-kenny-318175">Katherine Kenny</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a></em></p> <p>There have been incredible <a href="https://www.cancer.gov/types/breast/research">advances</a> in breast cancer diagnosis and treatment in recent years. And stories about celebrities who have “beaten” breast cancer continue to be a source of inspiration for many people.</p> <p>However, this emphasis on fighting, beating and surviving cancer shuts out the voices of those who will not survive. That is, the many people diagnosed with incurable, life-limiting metastatic breast cancer, <a href="https://www.aihw.gov.au/reports/cancer/cancer-data-in-australia">which kills nine Australians every day</a> or nearly <a href="https://www.aihw.gov.au/reports/cancer/cancer-data-in-australia">3,300 people</a> a year. Yet an <a href="https://www.bcna.org.au/latest-news/bcna-news/making-metastatic-breast-cancer-count/">estimated 10,000</a> Australians are living with the diagnosis.</p> <p>Being diagnosed with metastatic breast cancer, as one of the authors has been, means ongoing treatment to live as long, and as well, as possible. It also means an ongoing need for emotional and practical support.</p> <p>However, society, health-care professionals, cancer advocacy organisations, even a patient’s closest family and friends, can struggle to understand what it is like to live with an incurable and life-limiting cancer and how best to provide support.</p> <h2>Why is there so little awareness?</h2> <p><a href="https://www.breastcancer.org/types/metastatic">Metastatic breast cancer</a>, also called stage four breast cancer, is the most serious form of breast cancer. Unlike early breast cancer that is contained within the breast or nearby lymph nodes, metastatic breast cancer has spread to other parts of the body, most often the bones, lungs, liver, or brain.</p> <p>There is no cure for metastatic breast cancer despite decades of advocacy, funding and research. Treatment continues for as long as it helps to control the cancer and is tolerated by the patient. Median survival is <a href="https://onlinelibrary.wiley.com/doi/10.5694/mja2.51687">two to three years</a>, although newer, novel treatments mean some patients are living much longer.</p> <p>As a society, we can be uncomfortable <a href="https://theconversation.com/before-you-go-are-you-in-denial-about-death-34056">talking about and facing death</a>. When it comes to cancer, we usually prefer focusing on good news stories. These narratives are often perceived to be better for fundraising and are reassuring for people newly diagnosed. But they fail to <a href="https://onlinelibrary.wiley.com/doi/10.1111/1467-9566.13704">represent</a> the diversity and reality of cancer experiences.</p> <p>Despite considerable research into people with non-metastatic breast cancer, <a href="https://www.bcna.org.au/latest-news/bcna-news/making-metastatic-breast-cancer-count/">relatively little</a> is known about Australians with metastatic breast cancer.</p> <h2>Feeling silenced and unsupported</h2> <p>Through our <a href="https://onlinelibrary.wiley.com/doi/10.1111/1467-9566.13704">research</a> we wanted to better understand people’s experiences of metastatic breast cancer. We interviewed 38 participants from around Australia with diverse experiences of metastatic breast cancer. Participants were recruited through breast cancer and community organisations.</p> <p>We found messages and public campaigns about cancer survivorship, which emphasise hope and positivity, drowned out the voices of those with metastatic breast cancer. The focus on “success stories” about surviving breast cancer made some people feel like it was their responsibility to “beat” cancer. If they didn’t, it was their own fault. </p> <p>As one interviewee told us: "I react quite badly to all the, ‘we’ve had breast cancer and we beat it and we’ve survived. Aren’t we fantastic.’ There’s almost a feeling if you haven’t beaten your breast cancer you haven’t tried hard enough."</p> <p>Silence around metastatic breast cancer was common in research participants’ experiences. It prevented many from connecting with others and to the support they needed. It even affected relationships with those closest to them leaving them feeling misunderstood: "They don’t realise I’ve got to be on treatment forever. I’m not going to be cured. I think society thinks everything can be fixed; metastatic breast cancer actually can’t be fixed."</p> <p>Sharing deep fears and worries about their life expectancy can leave people with metastatic breast cancer feeling drained rather than supported. Many participants reported having to support and shield family, friends, acquaintances and work colleagues from the reality of their terminal diagnosis.</p> <p>"You hide how you feel because you don’t want to be avoided […] You put on that big, happy face. But like an onion if you peeled the layers away, you’d find out what’s going on."</p> <p>While many participants wanted to join a community of people with metastatic breast cancer, they struggled to know how to find one. Those who did, emphasised how invaluable it had been: "Being able to identify with and know that these people really get me is a huge relief and it reduces the isolation."</p> <p>These findings echo <a href="https://www.bcna.org.au/media/alcjjmm2/bcna_member-survey-report_2017.pdf">previous research</a> demonstrating people with metastatic breast cancer have higher support needs than those with non-metastatic breast cancer. And these needs are <a href="https://www.bcna.org.au/media/alcjjmm2/bcna_member-survey-report_2017.pdf">less likely to be met</a> by <a href="https://bmchealthservres.biomedcentral.com/articles/10.1186/s12913-022-08269-8">health care, support services</a>, family or friends.</p> <h2>A new path</h2> <p>Being diagnosed with metastatic breast cancer can be terrifying, lonely and create significant support needs. It is essential people with metastatic breast cancer have their <a href="https://ascopubs.org/doi/10.1200/OP.20.00183">voices listened to</a> and their needs met.</p> <p>Next steps should include:</p> <ul> <li> <p><a href="https://bcna-dxp.azureedge.net/media/d32bhdzf/bcna_making-metastatic-breast-cancer-count_2022.pdf">improving data collection by cancer registries</a> so we know exactly how many people in Australia have metastatic breast cancer</p> </li> <li> <p>increasing representation of people with metastatic breast cancer in advocacy, support organisations and research</p> </li> <li> <p>nationwide access to peer-to-peer programs and professionally led metastatic breast cancer support groups.</p> </li> </ul> <p>We must ensure people with metastatic breast cancer are the ones to speak to their experience and needs. As a colleague with metastatic breast cancer said: "I read an article written by an early-stage breast cancer ‘survivor’. It felt like someone describing winter when they had only ever experienced autumn."</p> <p>If you or someone you know has metastatic breast cancer, these organisations may be able to support you or connect you with others with the same diagnosis:</p> <ul> <li> <p><a href="https://www.bcna.org.au">Breast Cancer Network Australia</a> for information and support</p> </li> <li> <p><a href="https://www.mcgrathfoundation.com.au/">McGrath Foundation</a> for information about access to metastatic breast care nurses.</p> </li> </ul> <hr /> <p><em>The authors would like to thank the members of Breast Cancer Network Australia’s Metastatic Breast Cancer Lived Experience Reference Group for their review of this article.</em><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/215458/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em><a href="https://theconversation.com/profiles/sophie-lewis-111177">Sophie Lewis</a>, Senior Lecturer, University of Sydney, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a>; <a href="https://theconversation.com/profiles/andrea-smith-15431">Andrea Smith</a>, Research fellow, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a>, and <a href="https://theconversation.com/profiles/katherine-kenny-318175">Katherine Kenny</a>, ARC DECRA Senior Research Fellow, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a></em></p> <p><em>Image credits: Getty Images</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/im-not-going-to-be-cured-how-breast-cancer-awareness-and-support-sidelines-people-with-metastatic-disease-215458">original article</a>.</em></p>

Caring

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Marriage doesn’t cure reckless spending

<p><span style="font-family: inherit;">People who tend to splash their cash are unlikely to become more prudent after marriage, new research shows.</span></p> <p><span style="font-family: inherit;">Hisaki Kono from Japan’s Kyoto University and Tomomi Tanaka of the World Bank in Washington DC, US, studied 134 married couples in a middle-class area in Vietnam to see if spendthrift behaviour before marriage was moderated after getting hitched.</span></p> <p><span style="font-family: inherit;">The answer, <a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217646">published</a> in the journal PLOS One, is a resounding “not really”.</span></p> <p><span style="font-family: inherit;">The habit of splurging on impulse purchases is known in the jargon as “present bias”, defined by Kono and Tanaka as “the overvaluation of an immediate payoff”. It is a habit that often results in both short- and long-term problems, because it negatively impacts household budgets and savings bases. </span></p> <p><span style="font-family: inherit;">To test whether being married reduced present bias behaviour, the researchers interviewed all the husbands and wives individually, and asked them, as couples, to participate in a series of experiments that required them to make decisions about the allocation of imaginary funds. </span></p> <p><span style="font-family: inherit;">On the good news side of the ledger, the results showed that spendthrifty partners were less likely to be swayed by present bias when making joint financial decisions than when asked to make decisions on their own.</span></p> <p><span style="font-family: inherit;">However, present biased spouses were also likely to contribute smaller sums from their income for combined household spending. </span></p> <p><span style="font-family: inherit;">In situations where the profligate partner was in charge of the financial planning – something that occurred unexpectedly often – the more prudent partner was likely to be asked to put a higher proportion of income into the common pot.</span></p> <p><span style="font-family: inherit;">“Present-biased individuals also receive larger amounts of money from their spouses’ incomes, indicating that marriage not only fails to function as a savings commitment device but also exacerbates the problem,” the researchers write.</span></p> <p><span style="font-family: inherit;">They also noted that when prudent partners were in charge of finances, they tended to allocate only small amounts of spending money to their spouses – but that the recipients also tended to “conceal money to counteract this strategy”.</span></p> <p><span style="font-family: inherit;">The researchers tentatively suggest that in at least some partnerships unequal spending between partners was tolerated because of “the affection and acceptance that form the basis of marriage”, and because the union brought other, non-financial benefits, such as emotional support and protection.</span></p> <p><span style="font-family: inherit;">It is perhaps not surprising, however, that Kono and Tanaka found that women were more likely than men to be disadvantaged by a present-biased partner – and that they were therefore more likely to use external money-management strategies such as talking to financial advisers and locking funds up in savings accounts.</span></p> <p><em><span style="font-family: inherit;">Image credit: Getty Images</span></em></p> <p><em><span style="font-family: inherit;">This article first appeared on <a rel="noopener" href="https://cosmosmagazine.com/people/behaviour/marriage-doesnt-cure-reckless-spending-researchers-find/" target="_blank">cosmosmagazine.com</a> and was written by Andrew Masterson.</span></em></p>

Money & Banking

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The unlikely possible cure for epilepsy

<p><span style="font-weight: 400;">A small but highly venomous caterpillar from south-east Queensland might be the source of a new treatment for nervous system disorders like epilepsy.</span></p> <p><span style="font-weight: 400;">Studies at the University of Queensland’s Institute for Molecular Bioscience have pointed to a species of nettle caterpillar called </span><span style="font-weight: 400;">Doratifera vulnerans</span><span style="font-weight: 400;"> as a potential candidate for treatments.</span></p> <p><span style="font-weight: 400;">Andrew Walker, who has been studying the caterpillar’s venom since he found the species four years ago during a field trip, said “it’s strange biology and pain-causing venom fascinated me”.</span></p> <p><span style="font-weight: 400;">Dr Walker discovered that the insects were common in Queensland’s south-east, and said its defence mechanism saw it release up to 100 venom-producing spines on its back.</span></p> <p><span style="font-weight: 400;">“Its binomial name means ‘bearer of gifts of wounds’,” he said.</span></p> <blockquote style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" class="instagram-media" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/p/CQZk-pJlcT0/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="13"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"></div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"></div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"></div> </div> </div> <div style="padding: 19% 0;"></div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"></div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" rel="noopener" href="https://www.instagram.com/p/CQZk-pJlcT0/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank">A post shared by IMB (@imbatuq)</a></p> </div> </blockquote> <p><span style="font-weight: 400;">“I have been stung quite a lot of times by these caterpillars.</span></p> <p><span style="font-weight: 400;">“So the way the spine releases their venom is that they have closed but very thin and sharp tips,” he explained.</span></p> <p><span style="font-weight: 400;">“If you just lightly brush them, or touch them, the tips break off and the venom gets injected.”</span></p> <p><strong>Potential therapeutics</strong></p> <p><span style="font-weight: 400;">The UQ’s team recently published a report in </span><span style="font-weight: 400;">Proceedings of the National Academy of Sciences</span><span style="font-weight: 400;"> that found the venom is a source of peptides - smaller versions of proteins - that could be used to treat disorders affecting the nervous system, such as epilepsy.</span></p> <p><span style="font-weight: 400;">“Previously researchers had no idea what was in the venom nor how they induced pain,” Dr Walker said.</span></p> <p><span style="font-weight: 400;">“We’re right at the very start of … finding out about [the] venom and the toxins it contains.”</span></p> <p><span style="font-weight: 400;">Dr Walker said these peptides could be developed into medicines to help control the nervous system.</span></p> <p><span style="font-weight: 400;">“And [they would] allow us to ameliorate the effects of things like epilepsy, when the nervous system is too active,” he said.</span></p> <p><span style="font-weight: 400;">“So you want to calm [the nervous system] down a bit or, in other situations, you may want to activate certain parts of it.”</span></p> <p><span style="font-weight: 400;">Dr Robinson, the scientist responsible for researching which molecules in the venom caused the pain, said toxins have been used to help understand the human cardiovascular and nervous systems for decades.</span></p> <p><span style="font-weight: 400;">“My research program, for example, is centered on using toxins as tools to understand our sensory system, that is the neurons responsible for detecting and sending pain signals,” he said.</span></p> <p><span style="font-weight: 400;">“There really is no better place to look for new knowledge than nature.”</span></p> <p><strong>A new sheep-friendly pesticide</strong></p> <p><span style="font-weight: 400;">Dr Walker said, in addition to its potential therapeutic applications, that the venom could be used in the development of bio-friendly, eco-friendly insecticides to kill parasites in sheep.</span></p> <p><span style="font-weight: 400;">“First we discovered the structures of the toxins and then that allows us to design ways in the lab to make them,” he said.</span></p> <p><span style="font-weight: 400;">“Then, if we can make them in the lab, that will allow us to try to characterise them and work out what they do.”</span></p> <p><span style="font-weight: 400;">Some of the peptides already made in the lab through Dr Walker’s research have shown high potency and a potential to kill nematode parasites that are harmful to livestock.</span></p> <p><em><span style="font-weight: 400;">Image: imbatuq / Instagram</span></em></p>

Body

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Curing the incurable: A new breakthrough in childhood cancer

<p><span style="font-weight: 400;">Scientists are on the cusp of a medical breakthrough that could help in the treatment of an aggressive brain cancer.</span></p> <p><span style="font-weight: 400;">Diffuse Intrinsic Pontine Glioma, or DIPG, is the most aggressive childhood cancer with a </span><span style="text-decoration: underline;"><a href="https://www.ccia.org.au/blog/dipg-shining-a-light-on-the-deadliest-childhood-cancer"><span style="font-weight: 400;">current survival rate of 0%</span></a></span><span style="font-weight: 400;">. DIPG primarily occurs in children aged four to eleven years old and grows in the brainstem, meaning that it cannot be removed via surgery. On average, 20 Australian children are diagnosed with DIPG each year and have an average survival time of nine to twelve months after diagnosis.</span></p> <p><span style="font-weight: 400;">But now a new drug offers hope to patients diagnosed with the disease.</span></p> <p><span style="font-weight: 400;">Scientists at Children’s Cancer Institute have developed a new anti-cancer drug from antimalarial drug quinacrine. When tested on animals that were growing DIPG tumours, they found that the drug stopped tumour growth and, when combined with a second drug, panobinostat, increased survival time.</span></p> <blockquote style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" class="instagram-media" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/p/CNn7JQHAOCy/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="13"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"></div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"></div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"></div> </div> </div> <div style="padding: 19% 0;"></div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"></div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" rel="noopener" href="https://www.instagram.com/p/CNn7JQHAOCy/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank">A post shared by Children's Cancer Institute (@childrenscancerinstitute)</a></p> </div> </blockquote> <p><span style="font-weight: 400;">Associate Professor David Ziegler from </span><span style="text-decoration: underline;"><a href="https://www.ccia.org.au/blog/australian-researchers-find-new-way-to-target-deadly-childhood-cancer"><span style="font-weight: 400;">Children’s Cancer Institute</span></a></span><span style="font-weight: 400;"> said, “Over the years, many different types of treatments have been tried for DIPG, but none so far have proven effective in clinical trials of children with the disease.”</span><span style="font-weight: 400;"></span></p> <p><span style="font-weight: 400;">Speaking to Sunrise, he said the development was “a fantastic and exciting breakthrough.”</span><span style="font-weight: 400;"></span></p> <p><span style="font-weight: 400;">“This is one of the worst cancers to affect either children or adults and until now we’ve had no effective treatments,” he continued.</span><span style="font-weight: 400;"></span></p> <p><span style="font-weight: 400;">“We’re at the point where we’ve found a drug that looks really effective and is actually finally promising some hope.”</span><span style="font-weight: 400;"></span></p> <p><span style="font-weight: 400;">Ziegler will lead human trials of the drug in top children’s hospitals in the United States and Australia “by the end of this year”.</span><span style="font-weight: 400;"></span></p> <p><span style="font-weight: 400;">“We’re working as quickly as possible to bring this to kids who desperately need it,” Ziegler said.</span></p>

Body

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Nana’s cure proves scientific fact

<p>Australian Clinical Nutritionist, Warren Maginn said scientists are now verifying the evidence behind the popular wholefood panacea that has endured for centuries.</p> <p>“Our grandmothers swore by a spoonful of cod liver oil a day. Today resounding evidence shows that cod liver oil may be one of the safest, easiest ways to promote heart health, boost brain efficiency and support a healthy immune system” Mr Maginn said.</p> <p>“Cod liver oil is making a renaissance as recent studies have shown its rich omega-3 fatty acid profile, along with its naturally occurring levels of Vitamin A and Vitamin D having a multitude of health benefits”.</p> <p>A clinical trial which collected data from over 21,000 Norwegians has shown that regular use of cod liver oil is negatively associated with high levels of depressive symptoms in the general population.</p> <p>Another clinical trial on 341 pregnant women found maternal intake of Cod Liver Oil during pregnancy and lactation may be favourable for later mental development of children.</p> <p>Between 1998 and 2004, researchers followed nearly 40,000 Swedish men and recorded details of their diets. Men who consumed a moderate amount (about 0.3 grams a day) of omega-3 fatty acids in cod liver oil and other fish oils were less likely to develop heart failure than those who consumed little or no omega-3 fatty acids.</p> <p>Mr Maginn says, “While both fish oil and Cod Liver Oil are both good sources of the two most active omega-3s, EPA and DHA, they each provide slightly different ratios—Cod Liver Oil generally contains about 50% more DHA than EPA, whereas fish oil generally contains about 50% more EPA than DHA”.</p> <p>“This means that aside from its valuable Vitamin A and D content, Cod Liver Oil is particularly useful for supporting healthy brain and nervous system function, as well as the overall health of all body cells including those of the skin and glands that require more DHA in order to be at their best. Whilst Fish oils, with a higher EPA content, might lend themselves more specifically towards supporting inflammatory conditions such as arthritis and autoimmune diseases”.</p> <p>“The natural Vitamin A and D content of Cod Liver Oil provides further benefits to eyesight, bone strength and overall immune balance, such as improved wound healing and increased resistance to allergies and infections”.</p> <p><a rel="noopener" href="http://bit.ly/3boSdaY" target="_blank">Nordic Naturals Arctic Cod Liver Oil</a>™has been derived from 100% wild Arctic cod. Nordic Naturals Arctic Cod Liver Oil is vertically integrated from boat to bottle. By managing every step of the supply chain, Nordic Naturals ensure the exceptional quality, safety, and sustainability of the Arctic Cod Liver Oil™.</p> <p><strong>Three More Proven Nana Cures </strong></p> <ol> <li><strong>An apple a day!</strong> - Prescribing an apple a day to all adults aged 50 and over would prevent or delay around 8,500 vascular deaths such as heart attacks and strokes every year in the UK -- similar to giving statins to everyone over 50 years who is not already taking them -- according to a study.</li> <li><strong>Chicken soup will cure your cold</strong> – it may not cure you but it may help. Scientists now believe that a bowl of the soup may reduce inflammation of the lungs. It is thought that chicken soup slows down the activity of white blood cells that can cause the inflammation.</li> <li><strong>Honey for coughs</strong> – In a trial, honey did even better than the drug, coming out head and shoulders above the popular cough medication (dextromethorphan) at relieving cold and cough symptoms. Researchers believe the stickiness and viscosity of honey helps the cough, while the natural antioxidants can help in the healing process.</li> </ol> <p>Unlike other “cod liver oils” on the market, <a rel="noopener noreferrer" href="https://bit.ly/3sXow6L" target="_blank" data-auth="NotApplicable">Nordic Naturals Arctic Cod Liver Oil™</a> contains no fish body oils or synthetic vitamins or additives.</p> <p><u><a rel="noopener noreferrer" href="https://bit.ly/3sXow6L" target="_blank" data-auth="NotApplicable">Nordic Naturals award-winning Arctic Cod Liver Oil™</a></u> is an ideal choice to help boost immune system health during the colder months. Vertically integrated from catch to finished product, Arctic Cod Liver Oil far surpasses the strict European Pharmacopoeia Standard for fish oil purity and freshness. Simply put it’s some of freshest cod liver oil in the world.</p> <p>Nordic Naturals Arctic Cod Liver oil recently won in the 'Bone and Joint' category of the Good Magazine Best of Natural Awards.</p> <p>Available from all good health stores. To find a store near you visit <a rel="noopener" href="http://bit.ly/3ccOBrB" target="_blank">http://www.therahealth.com.au/store-locator</a></p> <p><strong><em>REFERENCES</em></strong></p> <ol> <li>Harrar S. Today’s Dietitian 2012; 14(1):22 Available at: http://www.todaysdietitian.com/newarchives/011012p22.shtml</li> <li>Bauer, I., Hughes, M., Rowsell, R., Cockerell, R., Pipingas, A., Crewther, S. and Crewther, D. (2014), Omega-3 supplementation improves cognition and modifies brain activation in young adults. Hum. Psychopharmacol. Clin. Exp.. doi: 10.1002/hup.2379</li> <li>A statin a day keeps the doctor away: comparative proverb assessment modelling study. BMJ 2013; 347 doi: http://dx.doi.org/10.1136/bmj.f7267 (Published 17 December 2013)</li> <li>Chicken soup inhibits neutrophil chemotaxis in vitro. 2000. Chest. 2009 Nov;136(5 Suppl):e29.</li> <li>A comparison of the effect of honey, dextromethorphan, and diphenhydramine on nightly cough and sleep quality in children and their parents. J Altern Complement Med. 2010 Jul;16(7):787-93. doi: 10.1089/acm.2009.0311.</li> </ol> <p><sup>1</sup><a rel="noopener" href="http://www.ncbi.nlm.nih.gov/pubmed/17184843" target="_blank"><strong> http://www.ncbi.nlm.nih.gov/pubmed/17184843</strong></a></p> <p><sup>1</sup><a rel="noopener" href="http://www.ncbi.nlm.nih.gov/pubmed/12509593" target="_blank"><strong>http://www.ncbi.nlm.nih.gov/pubmed/12509593</strong></a></p> <p><sup>1</sup><a rel="noopener" href="http://eurheartj.oxfordjournals.org/content/30/12/1495.abstract" target="_blank">http://eurheartj.oxfordjournals.org/content/30/12/1495.abstract</a></p> <div id="primary" class="contentAreaLeft"> <div class="Maincontent"> <p><strong><em>This is a sponsored article produced in partnership with <a rel="noopener noreferrer" href="https://therahealth.com.au/brands/nordicnaturals/" target="_blank">Thera Health</a>.</em></strong></p> </div> </div>

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15 vertigo treatments to finally cure your dizziness

<p>What is vertigo?<br />It’s the feeling of false movement – as if the world is spinning like a carnival ride and you can’t get off.</p> <p>It is a symptom of many conditions and diseases that target the inner ear, according to the National Organisation for Rare Disorders (NORD). They include:</p> <ul> <li>benign paroxysmal positional vertigo (BPPV)</li> <li>Ménière’s disease</li> <li>ear infections</li> </ul> <p>Other conditions that can cause vertigo involve the central nervous system. These include:</p> <ul> <li>concussion</li> <li>multiple sclerosis</li> <li>alcohol or medication toxicity</li> <li>stroke</li> <li>viral meningitis</li> </ul> <p>The vertigo treatment that’s right for you will likely depend on the root cause of your condition.” An accurate diagnosis is essential, especially to rule out central nervous system causes. Diagnosis most commonly includes an MRI of the brain. Audiology tests of the workings of the ear can also be helpful,” says neurologist, Arif Dalvi.</p> <p>Consider vestibular rehabilitation<br />Many of the conditions which cause vertigo affect the vestibular system, a pathway located within the inner ear which regulates balance, equilibrium and spatial orientation. According to VeDA – a group focused on inner ear disorders – vestibular rehabilitation therapy (VRT) can be effective at reducing vertigo and dizziness. VRT is an exercise-based program customised for each patient. The exercises focus on improving balance, reducing dizziness and dealing with other symptoms of vertigo. Your doctor will refer you to a physical therapist for this program.</p> <p>Try the Epley manoeuvre<br />“For benign paroxysmal positional vertigo (BPPV), a vestibular exercise called the Epley manoeuvre can be helpful,” says Dr Dalvi. BPPV is the most common cause of vertigo, and it’s the result of calcium crystals (otoconia) coming loose in the inner ear. According to the Mayo Clinic, the manoeuvre (also called “canalith repositioning“) is best performed by a medical professional because of the risk of neck or back injury. By laying back and then shifting the head, the process moves the crystals to a less sensitive area where they can be reabsorbed by the body. Your doctor will prescribe the Epley manoeuvre for right or left side BPPV.</p> <p>Change your diet<br />When migraines include vestibular symptoms such as dizziness, loss of balance and vertigo, they are called vestibular migraines. Alterations in your diet may be a good initial vertigo treatment. Changes in diet that help prevent migraines can reduce or even eliminate vertigo and other vestibular symptoms associated with this type of headache, according to VeDA. “From a dietary standpoint, it is important to avoid alcohol, foods high in salt, and excessive caffeine, as any of these can make symptoms worse,” says Dr Derek Bennetsen, emergency physician.</p> <p>Gently ride out the storm<br />Your vertigo may clear up on its own. Sometimes, says Dr Bennetsen, all you need is to lie down and remain calm and quiet. “Vertigo may be alleviated by remaining still, and limiting changes in position as much as possible,” says Dr Bennetsen. In a dark, quiet room, lie still taking care not to move your head or even your eyes, he says. Even if your symptoms resolve on their own, you’ll still want to get checked out, he advises.</p> <p>Take an antihistamine<br />As the name suggests, antihistamines block the effects of histamine, which can cause allergic reactions, nausea, vomiting, dizziness and vertigo. Internal medicine specialist, Lisa Ashe, recommends trying over-the-counter Benadryl or the prescription meclizine.</p> <p>Migraine medicines may help<br />A study published in Otology &amp; Neurotology in 2018 suggests that preventative medications for migraine, including tricyclic antidepressants, were effective in decreasing dizziness and vertigo in patients.</p> <p>Try sedatives<br />According to The American College of Cardiology (ACC), sedatives may reduce the spinning associated with vertigo by calming down brain activity and reducing anxiety. Dr Ashe recommends benzodiazepines, such as Valium, Ativan and Xanax. These medications may be a particularly effective vertigo treatment for reducing vertigo caused by inner ear problems, the ACC notes.</p> <p>Diuretics for Ménière’s disease<br />Ménière’s disease is an inner ear disorder that can trigger vertigo. Doctors often prescribe so-called water pills – diuretic medication – and a low-salt diet, says Dr Bennetsen: “This is because the condition is thought to be the result of an excessive build-up of endolymph fluid, in the inner ear.”</p> <p>Antiviral medications may help<br />Do you get earaches? Inner ear infections can lead to dizziness and – unlike middle-ear infections – a virus may be responsible. Occasionally, a systemic viral infection like mononucleosis, herpes or the flu can lead to vertigo, according to Cleveland Clinic. “Viral infections may respond to antiviral medications, alleviating symptoms,” says Dr Dalvi. Examples of anti-viral drugs include Tamiflu and Acyclovir.</p> <p>Drink more water<br />You need water – and so do your ears. Dehydration is a cause of dizziness, says the Mayo Clinic. Dr Bennetsen also recommends avoiding substances that can deplete fluids such as alcoholic beverages, salty foods and caffeine.</p> <p>Surgical solutions<br />In some rare instances, surgery may be the only treatment that can ease your symptoms of your vertigo. Dr Dalvi says an acoustic neuroma – a benign tumour – can grow on the vestibular nerve between the inner ear and brain, disrupting balance and hearing. According to the Mayo Clinic, your doctor may monitor this slow-growing neuroma, choose to treat it with radiation or advise surgical removal. Another rare source of vertigo is a malignant brain tumour.</p> <p>Check your medications<br />Many popular prescribed medications can trigger side effects like dizziness and vertigo. Or drugs can interact to disturb your balance. Let your doctor know about over-the-counter meds you take and don’t forget to include supplements and herbs. According to the experts at the Mayo Clinic, prescriptions and over-the-counter drugs that may cause dizziness include:</p> <ul> <li>antidepressants</li> <li>anti-seizure drugs</li> <li>blood pressure-lowering drugs</li> <li>sedatives</li> <li>tranquilisers</li> </ul> <p>Healthy habits may help<br />A healthy lifestyle is another vertigo prevention strategy that you need to do no matter what the cause. Try reducing stress and making sure to get enough sleep. Eat a diet full of produce and lean proteins, and stay active (given your condition).</p> <p>Bone up on vitamin D<br />Falling short of this vital nutrient can harm your bones – your body needs vitamin D to absorb calcium. Patients with the most common type of vertigo (BPPV) who were deficient in vitamin D may have benefitted from supplementing with D, per 2016 research in Auris Nasus Larynx. Patients were less likely to suffer a relapse of symptoms. (One limitation, however, was the lack of control group in the study.)</p> <p class="p1"><em>Written by Corey Whelan. This article first appeared on <a href="https://www.readersdigest.com.au/healthsmart/15-vertigo-treatments-to-finally-cure-your-dizziness"><span class="s1">Reader’s Digest</span></a>. For more of what you love from the world’s best-loved magazine, <a href="http://readersdigest.com.au/subscribe"><span class="s1">here’s our best subscription offer</span></a>.</em></p>

Body

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Dolly did it! Fans praise Dolly Parton for "curing coronavirus"

<div class="post_body_wrapper"> <div class="post_body"> <div class="body_text redactor-styles redactor-in"> <p><span>Dolly Parton has been praised by country music fans for "playing an important role in the COVID battle" after making a very generous donation.</span></p> <p>She gave USD $1 million to the Vanderbilt University Medical Centre in Nashville to fund coronavirus projects.</p> <p>One of these projects were human trials of the Moderna vaccine, which was found this week to be nearly 95 per cent effective against the virus in early studies.</p> <p>A Vanderbilt spokesperson said Parton’s “generous” gift was helping “several promising research initiatives”.</p> <blockquote class="twitter-tweet"> <p dir="ltr">When I donated the money to the Covid fund I just wanted it to do good and evidently, it is! Let’s just hope we can find a cure real soon. <a href="https://t.co/dQgDWexO0C">pic.twitter.com/dQgDWexO0C</a></p> — Dolly Parton (@DollyParton) <a href="https://twitter.com/DollyParton/status/1328741440470528000?ref_src=twsrc%5Etfw">November 17, 2020</a></blockquote> <p>Fans are saying that "Dolly is our saviour" and others are saying that as she donated to the researchers that are now helping with the vaccine, she helped cure COVID.</p> <p>Dolly announced her generous donation to the Medical Center back in May.</p> <p>“My longtime friend Dr Naji Abumrad, who’s been involved in research at Vanderbilt for many years, informed me that they were making some exciting advancements towards that research of the coronavirus for a cure,” the star wrote on Instagram.</p> <p>“I am making a donation of $1 million to Vanderbilt towards that research and to encourage people that can afford it to make donations.”</p> </div> </div> </div>

Music

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Teenager leads discovery in finding COVID-19 cure

<p>Scientists across the globe are on a race to find a treatment for COVID-19, however the standout in all of this is a teenage girl. </p> <p>Anika Chebrolu, a 14-year-old from Frisco, Texas, has just won the 2020 3M Young Scientist Challenge and a whopping A$35,230 prize for a discovery that could give a potential therapy to COVID-19.</p> <p>Anika's invention that won the prize uses in-silico methodology to uncover a lead molecule that can bind to the spike protein of the SARS-CoV-2 virus.</p> <p>The teen submitted her project while she was in the 8th grade, but she admitted her goal was not initially to find a cure for COVID-19. </p> <p>Her original intention was to use in-silico methods to identify a lead compound that could bind to a protein of the influenza virus. </p> <p>"After spending so much time researching about pandemics, viruses and drug discovery, it was crazy to think that I was actually living through something like this," Anika said.</p> <p>"Because of the immense severity of the COVID-19 pandemic and the drastic impact it had made on the world in such a short time, I, with the help of my mentor, changed directions to target the SARS-CoV-2 virus."</p> <p>Anika revealed she was inspired to find potential cures to viruses after learning about the 1918 flu pandemic. </p> <p>"Anika has an inquisitive mind and used her curiosity to ask questions about a vaccine for COVID-19," Dr Cindy Moss, a judge for the 3M Young Scientist Challenge, told CNN.</p> <p>"Her work was comprehensive and examined numerous databases. She also developed an understanding of the innovation process and is a masterful communicator. Her willingness to use her time and talent to help make the world a better place gives us all hope."</p> <p>Anika said winning the prize and title of top young scientist is an honour, but her work is not completed. </p> <p>Her next goal is to research and work alongside scientists and researchers who are fighting to "control the morbidity and mortality" of the pandemic. </p> <p>She will aid in developing her findings into an actual cure for the virus.</p> <p>"My effort to find a lead compound to bind to the spike protein of the SARS-CoV-2 virus this summer may appear to be a drop in the ocean, but still adds to all these efforts," she said.</p> <p>"How I develop this molecule further with the help of virologists and drug development specialists will determine the success of these efforts."</p> <p><em>Image Credit: NIAID-RML (AP/NIAID-RML)</em></p>

Caring

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Alzheimer’s breakthrough discovery

<p>Australian researchers are optimistic as they believe they have discovered a treatment that could revise the impacts of memory loss in people suffering from Alzheimer’s disease.</p> <p>The Macquarie University Dementia Research Centre study builds on previous research that found an enzyme in the brain could modify a protein so it prevents the development of Alzheimer’s symptoms.</p> <p>The latest research went further by finding the gene responsible for the enzyme that could help restore or improve memory in mice suffering from advanced Alzheimer’s disease.</p> <p>The study also suggests the gene therapy, which involves genetic material being introduced to cells to help replace abnormal genes, may also be helpful for those who are in their 40s and 50s and suffer from dementia.</p> <p>Researchers have discovered gene therapy is safe when given in high doses and for a long period of time.</p> <p>Dr Arne Ittner, one of the leaders of the study, says a better understanding is required of what happens to the molecules in the brain during dementia.</p> <p>"Our work delivers a very powerful piece in this puzzle," he said in a statement.</p> <p>His brother and co-research leader, Professor Lars Ittner, said he was ecstatic to see a decade worth of research transition into clinical development that could benefit those living with dementia.</p> <p>"This provides hope as there is a lot of therapy out there focused on prevention but not much for those already affected by the disease," he said.</p> <p>The two researchers said the possible success of this new therapy could be within reach in five to 10 years.</p>

Retirement Life

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“Major breakthrough”: Scientists find new drug to save COVID-19 patients’ lives

<p>A cheap and widely accessible steroid called dexamethasone has become the first drug that has been shown to save lives among COVID-19 patients.</p> <p>Scientists have hailed it as a “major breakthrough” after trials showed that the drug reduced death rates by around a third of the most severely ill COVID-19 patients admitted to hospital.</p> <p>Dexamethasone is used to reduce inflammation in other diseases and the success of the drug suggest that it should immediately become standard care in patients with severe cases of the pandemic disease.</p> <p>“This is a result that shows that if patients who have COVID-19 and are on ventilators or are on oxygen are given dexamethasone, it will save lives, and it will do so at a remarkably low cost,” said Martin Landray, an Oxford University professor co-leading the trial.</p> <p>“It’s going to be very hard for any drug really to replace this, given that for less than STG50 ($A90) you can treat eight patients and save a life,” he told reporters in an online briefing.</p> <p>Co-lead investigator Peter Horby said that dexamethasone was “the only drug that’s so far shown to reduce mortality and it reduces it significantly”.</p> <p>“It is a major breakthrough,” he said.</p> <p>“Dexamethasone is inexpensive, on the shelf, and can be used immediately to save lives worldwide.”</p> <p>There are currently no approved treatments or vaccines for COVID-19, a disease that has killed more than 431,000 globally.</p> <p>“The survival benefit is clear and large in those patients who are sick enough to require oxygen treatment, so dexamethasone should now become standard of care in these patients,” Horby said.</p>

Caring

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Warnings over church selling bleach as coronavirus cure

<p>The Australian chapter of an international church that peddles bleach as a “miracle cure” for coronavirus and other illnesses is selling the product locally.</p> <p>The Genesis II Church of Health and Healing sells industrial-grade bleach as “Master” or “Miracle Mineral Solution” – also known as MMS – claiming it can cure COVID-19 as well as autism, HIV/AIDS, leukemia and acne.</p> <p>The US leader of the organisation, Mark Grenon, said the chlorine dioxide product could “kill 99 per cent of the pathogens in the body”. A post on the Genesis website said MMS could have side effects, including stomach pain and diarrhea.</p> <p>Grenon claimed he wrote to Donald Trump about its “sacramental cleansing water” days before the US president suggested injecting disinfectant to treat coronavirus.</p> <p>MMS is not approved for consumption in Australia and the United States. Australia’s Therapeutic Goods Administration (TGA) warned that MMS should be labelled as “poison” after <a href="https://www.tga.gov.au/alert/miracle-mineral-solution-mms">four people in Victoria were hospitalised in 2014</a> following the consumption of the product.</p> <p>Last week, a US federal court <a href="https://www.bradenton.com/news/local/article242484731.html">issued a ban on the organisation from selling and distributing its products</a>. Judge Kathleen Williams said a preliminary injunction needed to be issued to prevent the Genesis from further violating the federal laws on food, drug and cosmetics.</p> <p>In a complaint seeking the preliminary injunction, the US Food and Drug Administration said MMS was a misbranded and unapproved drug with “no published adequate and well-controlled studies” to support its treatment claims.</p> <p>In late 2019, the agency also said it had received reports of consumers who suffered “from severe vomiting, severe diarrhea, life-threatening low blood pressure caused by dehydration, and acute liver failure after drinking these products”.</p> <p>Professor Andrew Dawson, the clinical director of the NSW Poisons Information Centre, said four people in the state had to be hospitalised last year after taking MMS.</p> <p>“I’m also aware of a patient in Queensland who became extremely sick and was hospitalised for several weeks,” Dawson told ABC’s <em><a href="https://www.abc.net.au/news/2020-05-05/church-selling-bleach-claims-cures-coronavirus-australia/12201348">7.30</a></em>.</p> <p>Charles Barton, who runs the MMS Australia website, told the program MMS was “innocent and perfectly safe”.</p> <p>The TGA told the program it was investigating MMS Australia.</p>

News

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Malaria and arthritis drugs touted as potential coronavirus “cure”

<p>Pharmacists have been ordered to stop dispensing two drugs touted as potential “cures” for the new coronavirus.</p> <p>Australian pharmacies saw a major rush for old malaria drugs hydroxychloroquine – sold as Plaquenil – and chloroquine after US President Donald Trump touted the medications as a “game changer” in a press conference last week.</p> <p>The comment was based on a recent <a href="https://drive.google.com/file/d/186Bel9RqfsmEx55FDum4xY_IlWSHnGbj/view">patient trial of hydroxychloroquine for COVID-19 conducted in Marseilles</a>, France, which reported “<a href="https://www.forbes.com/sites/marybethpfeiffer/2020/03/18/science-works-to-use-old-cheap-drugs-to-attack-coronavirus--it-might-just-work/#481669275c49">encouraging</a>” early results.</p> <p>Pharmaceutical Society of Australia president Chris Freeman said the unprecedented demand for the drugs in pharmacies across Australia created a shortage for patients who actually needed them.</p> <p>The two medications are also used to treat rheumatoid arthritis.</p> <p>Freeman said despite “positive signals” from the trial, people should not “buy into the hype”.</p> <p>“I think the worst thing that could happen is people start using these medicines in the hope it will prevent the virus, and then relax on other measures to prevent [it],” Freeman told the <em><a href="https://www.abc.net.au/news/2020-03-23/malaria-drugs-labelled-early-coronavirus-covid19-cures-treatment/12081306">ABC</a></em>.</p> <p>Freeman has asked pharmacists to keep their supplies of hydroxychloroquine safe.</p> <p>“We’re calling all prescribers to stop prescribing these in the short term until we have some more evidence on whether these medicines are effective in these conditions and are safe to do so,” he said.</p> <p>The Australian Medical Association have also supported the pharmacists’ call for GPs and doctors to stop prescribing the drug.</p> <p>The trial, which studied 36 patients, found that 70 per cent of the hydroxychloroquine-treated group tested negative to the virus at day 6.</p> <p>Ying Zhang, a professor of microbiology at Johns Hopkins Bloomberg School of Public Health, said the Marseilles study had “potentially interesting and justified” findings, but was limited by a small sample size and a <a href="https://www.forbes.com/sites/marybethpfeiffer/2020/03/22/one-patient-dodges-a-covid-bullet-is-she-a-harbinger-or-outlier/#8762c745b843">short treatment and follow-up duration</a>.</p> <p>Christian Perronne, a infectious diseases physician at Greater Paris University Hospitals, said the results were “very encouraging” but added: “I agree with authorities and colleagues that, before recommending this treatment on a large scale, this efficacy should be further studied on a bigger number of patients with a longer follow-up.”</p> <p>According to <em><a href="https://www.vox.com/2020/3/20/21188433/coronavirus-hydroxychloroquine-chloroquine-covid-19-treatment">Vox</a></em>, at least <a href="https://clinicaltrials.gov/ct2/results?cond=COvid-19&amp;term=hydroxychloroquine&amp;cntry=&amp;state=&amp;city=&amp;dist=">six clinical trials for hydroxychloroquine</a> are enrolling patients or in planning stages around the world.</p>

Body

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“A magic bullet”: New leukemia treatment available can cure aggressive cancer

<p>Researchers at Royal Perth Hospital are thrilled that they’ve helped uncover a new drug that can cure an aggressive type of Leukemia.</p> <p>It’s been dubbed “the magic bullet” as retiree Howard Kurth, 80, was diagnosed with Acute Myeloid Leukaemia two years ago.</p> <p>He told<span> </span><em><a rel="noopener" href="https://www.9news.com.au/good-news/news-perth-new-leukemia-treatment-dubbed-a-magic-bullet/c2a61f8d-5d5a-49da-aecf-a4dcc2e30fc1" target="_blank">Nine News Perth</a></em><span> </span>that he had just days to live.</p> <p>"There was absolutely no sign of tiredness or soreness or anything," he said.</p> <p>"It was just a shot out of the blue."</p> <p>Howard was riddled with the deadly disease as it had made its way through more than 90 per cent of his body.</p> <p>His health was so bad that he wasn’t eligible for normal chemotherapy, but with this new treatment, he’s just celebrated his 80th birthday.</p> <p>Howard went into remission within four months of starting the new treatment and is still in remission two years later.</p> <p>"I thought, 'Well, I am going to beat this, there's no two ways about it', and so far I have," he said.</p> <p>He is the first patient in Australia to undergo the treatment and the treatment requires two pills taken every day and a small injection of chemotherapy seven days a month.</p> <p>Dr Peter Tan, from Royal Perth Hospital, says they are now using the results to personalise treatments.</p> <p>"What we're trying to find are certain markers to personalise treatment for patients as we know a one-size-fits-all doesn't help everybody," he said.</p> <p>"We think it will change the standard therapy and once it does become available for all patients, it will be the new gold standard across the world." </p>

Body

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Eating chocolate won't cure depression

<p>A study published in the journal <a href="https://onlinelibrary.wiley.com/doi/full/10.1002/da.22950"><em>Depression and Anxiety</em></a> has attracted <a href="https://7news.com.au/lifestyle/health-wellbeing/dark-chocolate-could-boost-mood-study-c-378548">widespread media attention</a>. Media reports <a href="https://www.google.com/search?q=chocolate+depression&amp;client=firefox-b-d&amp;source=lnms&amp;tbm=nws&amp;sa=X&amp;ved=0ahUKEwjYuqGh14PkAhXX73MBHRnOAysQ_AUIEygD&amp;biw=1522&amp;bih=687">said</a> eating chocolate, in particular, dark chocolate, was linked to reduced symptoms of depression.</p> <p>Unfortunately, we cannot use this type of evidence to promote eating chocolate as a safeguard against depression, a serious, common and sometimes debilitating mental health condition.</p> <p>This is because this study looked at an <em>association</em> between diet and depression in the general population. It did not gauge causation. In other words, it was not designed to say whether eating dark chocolate <em>caused</em> a reduction in depressive symptoms.</p> <p><strong>What did the researchers do?</strong></p> <p>The authors explored data from the United States <a href="https://www.cdc.gov/nchs/nhanes/index.htm">National Health and Nutrition Examination Survey</a>. This shows how common health, nutrition and other factors are among a representative sample of the population.</p> <p>People in the study reported what they had eaten in the previous 24 hours in two ways. First, they recalled in person, to a trained dietary interviewer using a standard questionnaire. The second time they recalled what they had eaten over the phone, several days after the first recall.</p> <p>The researchers then calculated how much chocolate participants had eaten using the average of these two recalls.</p> <p>Dark chocolate needed to contain at least 45 per cent cocoa solids for it to count as “dark”.</p> <p>The researchers excluded from their analysis people who ate an implausibly large amount of chocolate, people who were underweight and/or had diabetes.</p> <p>The remaining data (from 13,626 people) was then divided in two ways. One was by categories of chocolate consumption (no chocolate, chocolate but no dark chocolate, and any dark chocolate). The other way was by the amount of chocolate (no chocolate, and then in groups, from the lowest to highest chocolate consumption).</p> <p>The researchers assessed people’s depressive symptoms by having participants complete a short questionnaire asking about the frequency of these symptoms over the past two weeks.</p> <p>The researchers controlled for other factors that might influence any relationship between chocolate and depression, such as weight, gender, socioeconomic factors, smoking, sugar intake and exercise.</p> <p><strong>What did the researchers find?</strong></p> <p>Of the entire sample, 1,332 (11 per cent) of people said they had eaten chocolate in their two 24 hour dietary recalls, with only 148 (1.1 per cent) reporting eating dark chocolate.</p> <p>A total of 1,009 (7.4 per cent) people reported depressive symptoms. But after adjusting for other factors, the researchers found no association between any chocolate consumption and depressive symptoms.</p> <p>However, people who ate dark chocolate had a 70 per cent lower chance of reporting clinically relevant depressive symptoms than those who did not report eating chocolate.</p> <p>When investigating the amount of chocolate consumed, people who ate the most chocolate were more likely to have fewer depressive symptoms.</p> <p><strong>What are the study’s limitations?</strong></p> <p>While the size of the dataset is impressive, there are major limitations to the investigation and its conclusions.</p> <p>First, assessing chocolate intake is challenging. People may eat different amounts (and types) depending on the day. And asking what people ate over the past 24 hours (twice) is not the most accurate way of telling what people usually eat.</p> <p>Then there’s whether people report what they actually eat. For instance, if you ate a whole block of chocolate yesterday, would you tell an interviewer? What about if you were also depressed?</p> <p>This could be why so few people reported eating chocolate in this study, compared with what <a href="https://www.forbes.com/sites/niallmccarthy/2015/07/22/the-worlds-biggest-chocolate-consumers-infographic/#718514644847">retail figures</a> tell us people eat.</p> <p>Finally, the authors’ results are mathematically accurate, but misleading.</p> <p>Only 1.1 per cent of people in the analysis ate dark chocolate. And when they did, the amount was very small (about 12g a day). And only two people reported clinical symptoms of depression and ate any dark chocolate.</p> <p>The authors conclude the small numbers and low consumption “attests to the strength of this finding”. I would suggest the opposite.</p> <p>Finally, people who ate the most chocolate (104-454g a day) had an almost 60 per cent lower chance of having depressive symptoms. But those who ate 100g a day had about a 30 per cent chance. Who’d have thought four or so more grams of chocolate could be so important?</p> <p>This study and the media coverage that followed are perfect examples of the pitfalls of translating population-based nutrition research to public recommendations for health.</p> <p>My general advice is, if you enjoy chocolate, go for darker varieties, with fruit or nuts added, and eat it <a href="https://theconversation.com/we-dont-yet-fully-understand-what-mindfulness-is-but-this-is-what-its-not-110698">mindfully</a>. — <strong>Ben Desbrow</strong></p> <p><strong>Blind peer review</strong></p> <p>Chocolate manufacturers have been a good source of <a href="https://forbetterscience.com/2016/05/19/chocolate-is-good-for-your-funding/">funding</a> for much of the <a href="https://www.foodpolitics.com/2015/10/heres-why-food-companies-sponsor-research-mars-inc-s-cocoavia/">research</a> into chocolate products.</p> <p>While the authors of this new study declare no conflict of interest, any whisper of good news about chocolate attracts publicity. I agree with the author’s scepticism of the study.</p> <p>Just 1.1 per cent of people in the study ate dark chocolate (at least 45 per cent cocoa solids) at an average 11.7g a day. There was a wide variation in reported clinically relevant depressive symptoms in this group. So, it is not valid to draw any real conclusion from the data collected.</p> <p>For total chocolate consumption, the authors accurately report no statistically significant association with clinically relevant depressive symptoms.</p> <p>However, they then claim eating more chocolate is of benefit, based on fewer symptoms among those who ate the most.</p> <p>In fact, depressive symptoms were most common in the third-highest quartile (who ate 100g chocolate a day), followed by the first (4-35g a day), then the second (37-95g a day) and finally the lowest level (104-454g a day). Risks in sub-sets of data such as quartiles are only valid if they lie on the same slope.</p> <p>The basic problems come from measurements and the many confounding factors. This study can’t validly be used to justify eating more chocolate of any kind. — <strong>Rosemary Stanton</strong><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: http://theconversation.com/republishing-guidelines --></p> <p><span><em>Written by Ben Desbrow, Associate Professor, Nutrition and Dietetics, Griffith University. Republished with permission of </em><a rel="noopener" href="https://theconversation.com/no-eating-chocolate-wont-cure-depression-121504" target="_blank"><em>The Conversation</em></a><em>. </em></span></p>

Mind

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Will you try these extreme holiday cures?

<p><span style="font-weight: 400;">You thrive on adventure, live for the unforgettable experience, there’s just one little thing that scares you…</span></p> <p>Frightened of sharks? <span style="font-weight: 400;">Get up close and personal with the ocean’s most majestic creatures at Beqa Island in Fiji. With no cages or barriers between you and the sharks, you can swim with eight different species including bull sharks, reef sharks, grey nurses and the awe-inspiring tiger shark.</span></p> <p>Frightened of heights? <span style="font-weight: 400;">Take a bungee jumping adventure up a notch by diving head first into an active volcano. A helicopter will fly you into the caldera of a volcano near Pucon, Chile, so you can bungee-jump within 200m of molten lava below.</span></p> <p>Frightened of speed? <span style="font-weight: 400;">Some of the world’s best desert dunes are in the Wahiba Sands, a two-hour drive from Muscat, the capital of Oman. With many about 100m in height, this is the perfect place for some extreme sandboarding action. If you’re not prepared to fly down the dunes standing up, you can warm up by tobogganing down instead.</span></p> <p>Frightened of rats? <span style="font-weight: 400;">Karni Mata Temple in Rajasthan, India, is just what you need to face your fears. Also called the Temple of the Rats, it’s famous for both its beautiful architecture and the 20,000-odd rats that call it home.</span></p> <p><span style="font-weight: 400;">This article first appeared in </span><a href="https://www.readersdigest.com.au/travel/activities/extreme-holiday-cures"><span style="font-weight: 400;">Reader’s Digest</span></a><span style="font-weight: 400;">. For more of what you love from the world’s best-loved magazine, </span><a href="http://readersdigest.innovations.com.au/c/readersdigestemailsubscribe?utm_source=over60&amp;utm_medium=articles&amp;utm_campaign=RDSUB&amp;keycode=WRA87V"><span style="font-weight: 400;">here’s our best subscription offer.</span></a></p> <p><img style="width: 100px !important; height: 100px !important;" src="https://oversixtydev.blob.core.windows.net/media/7820640/1.png" alt="" data-udi="umb://media/f30947086c8e47b89cb076eb5bb9b3e2" /></p>

Cruising

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5 steps to stop a nosebleed

<p>Nosebleeds (or epistaxis) are fairly common, especially in children. They usually happen as a result of a minor injury, nose picking, or nose blowing. Occasionally, nosebleeds can signal underlying illness or injury. Very rarely, a nosebleed can be life-threatening, especially in older people. Treating a nosebleed incorrectly can prolong bleeding and make things worse. Follow these five steps to handle a nosebleed.</p> <p><strong>1. Sit the patient down.</strong></p> <p>Ask them to lean forwards (not backwards) so that the blood drains away from the nose, not down the throat. Wear disposable gloves if you have them to protect yourself and the patient.</p> <p><strong>2. Pinch the nose.</strong></p> <p>Tell the patient to breathe through their mouth and pinch the soft part of their nose to help reduce blood flow, blocking the nostrils. He or she can lean over a sink or a bowl so that they can spit out any blood as swallowing it can make them sick. Advise them not to sniff, swallow, or cough, as it can disturb the clots that are forming.</p> <p><strong>3. Check the nose.</strong></p> <p>After ten minutes, release the pressure and check the nose. If still bleeding, pinch the nose for another ten minutes.</p> <p><strong>4. Offer a cold compress.</strong></p> <p>Give the patient an ice or cold pack to hold against the bridge of their nose to help reduce blood flow.</p> <p><strong>5. Check the nose again.</strong></p> <p>Once the bleeding has stopped, let the patient clean around their nose with a damp cloth. Tell them not to blow their nose and avoid strenuous activity for up to 12 hours.</p> <p><strong>Seek medical advice for a nosebleed if you have:</strong></p> <ul> <li>Frequent nosebleeds (more than once a week) – this can be a sign of high blood pressure.</li> <li>Persistent nosebleeds in a person who is on blood-thinning medication such as Warfarin.</li> <li>Thin watery blood from the nose following a blow to the head, which can indicate a possible skull fracture.</li> <li>Frequent nosebleeds accompanied by bleeding gums as well as bruises that develop for no apparent reason.</li> </ul> <p><em>This article first appeared in </em><a href="http://www.readersdigest.com.au/healthsmart/tips/5-Steps-to-Stop-a-Nosebleed"><em>Reader’s Digest</em>.</a><em> For more of what you love from the world’s best-loved magazine, </em><a href="http://readersdigest.innovations.com.au/c/readersdigestemailsubscribe?utm_source=over60&amp;utm_medium=articles&amp;utm_campaign=RDSUB&amp;keycode=WRA93V"><em>here’s our best subscription offer.</em></a></p> <p><img style="width: 100px !important; height: 100px !important;" src="https://oversixtydev.blob.core.windows.net/media/7820640/1.png" alt="" data-udi="umb://media/f30947086c8e47b89cb076eb5bb9b3e2" /></p>

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